Today, much attention is being paid to the prevention of cardiovascular diseases. In some parts of the world, the rate of cardiovascular disease is low due to a Mediterranean diet containing olive oil. This systematic review examined the verses and traditions in order to express opinions on olive and compare it with the findings of modern medicine. methods : this is a qualitative systematic review of studies in which data were collected from Qur’an , traditions , and related articles on the internet , limited to English and Persian and without time limitation by using the keywords olive , heart disease and Mediterranean diet. Results: this systematic review demonstrated that olive in the Quran is a clear sign to scientists. Moreover, its use is recommended in the authentic traditions. Conclusion: based on the results, olive has been found to be effective in reducing mortality and preventing cardiovascular diseases.