According to Muslims beliefs, Quran is the last scripture and final message of god for mankind. Several theories have been proposed regarding characteristics and features of this Scripture, and one of them is Quran comprehensiveness theory. According to this theory Quran has stated whatever human needs in worldly and otherworldly terms. Quran comprehensiveness theory is considered as fundamental principles to understanding and perceiving the Quran, and acceptance or denial of that has an impact on interpretation of this Holy book. This theory has many reasons and evidence in Muslims texts. This paper attempts to investigate most significant anecdotal and intellectual reasons of Quran comprehensiveness theory.