Free radicals are known as atoms and molecules which are highly reactive with the body’s single-electrons, and may cause irrecoverable damages to the macromolecules of organisms. Systems to deal with damages caused by free radicals are known as “antioxidant immune systems”. Flavonoids and polyphenol compounds are from non-enzymatic antioxidants which many nutritional compounds contain them. Evidence Acquisitions : The current study is a review survey conducted by evaluating the texts , library and internet search for the keywords such as antioxidant , flavonoid , nutrition , and Quran in the Persian documentaries of Google , scientific information database (SID) , ministry of healthcare , medical articles library of Iran (medlib.ir) , Iranian research institute for information (IranDoc) , publication database (Magiran , Iranmedex) , and also search in other electronic databases such as Google Scholar , Scopus and PubMed. Results: Data gathering instrument of the present study was all published texts regarding Quran and antioxidants. To conduct the current study, 31 references were used. Conclusions: Today, scientific medical studies have demonstrated that antioxidants are necessary for health. Quran, the Muslims’ Holy Book, has noted this important matter and has introduced many antioxidants in different versus. Infallible Imams (AS) also have many hadiths in this regard. These foodstuffs include pomegranate, honey, olive, grapes, and garlic.