The human nature has an inner tendency toward harmony and rhythm and enjoys order and coordination. The Holy Quran has an eloquent expression, a fluent style and an enchanting song that affects the audience. During the past two decades, research in the area of Quran lilt and medical science in Iran has been seriously followed. The present study has been conducted aiming at investigating and analyzing the studies undertaken in relation with the Holy Quran lilt and the health domain in Iran. Conclusion: The valuable results of the influence of Quran lilt especially in the area of mental health are obvious and clear. Physicians, nurses and sociologists, beside the psychological and medication methods, can use the inspiring words of revelation to reduce their patients’ problems and ask clients to have religious behaviors such as Quran reading in their life schedule to reduce their stress and worries.