Since most of the fruits are rich in vitamins, minerals, and salts they often have significant effects on human health; hence, continuous consumption of fruits, because of water, sugar, fat, protein, vitamins, and etc. play a significant role in prevention and treatment of many diseases. In this regard, Holy Quran, the book of healing and mercy, has dragged human attention toward certain fruits such as grape, olive, pomegranate, date, and fig. Certainly, there are physical and mental benefits to humans, in this notice of Knowing God. The current study aimed to evaluate therapeutic properties of Quranic fruits and their effects on health promotion. Evidence Acquisitions: The current study was a review research which was conducted according to Islamic references such as Holy Quran and Islamic interpretations, medical narratives, traditional and modern medicine books, published articles, and advanced internet search. Results : In Holy Quran, God has mentioned grape 11 times , olive 6times , pomegranate 3 times , date once (palm tree 20 times), and fig once. Of course, in one case olive has been indirectly mentioned. Note that, these fruits have been mentioned together, in some verses; such as Surah At-tin verse 1: “by the fig and the olive!”. From another side, traditional medicine books and modern clinical findings show that these fruits are effective in the treatment of cancers, cardio-vascular diseases, Alzheimer, hyper tension, bad cholesterol, infection and inflammation, and also improvement of immune system, and health of various body organs. Conclusions: After evaluating traditional medicine books and modern medical findings about the properties of Quranic fruits and their effects, it was concluded that consumption of any one of these fruits (grape, olive, pomegranate, date, and fig) in daily diet, plays significant role in health promotion.